The Omicron variant,
spreading now in southern Africa and detected in over 30 other countries and
regions, has prompted fears it could significantly undermine the effectiveness
of vaccines against COVID-19.
Yet as scientists race to understand the full consequences of
Omicron, some are also asking whether this new version of coronavirus might
cause milder illness than its predecessors.
What does data show?
The collected data showed among 70 cases reported in Europe that
included information on disease severity, half of the patients had no symptoms
and half had mild symptoms, according to a report on Thursday by the European
Center for Disease Prevention and Control.
There were no cases of severe disease, hospitalization, or
death. However, the European agency said it would require data on hundreds of
cases to accurately assess disease complications, estimating that could take
several weeks. In addition, most cases detected in Europe so far have been in
younger people who were fully vaccinated, making them less likely to suffer
severe illness.
In South Africa, where the daily number of reported COVID-19
cases doubled on Wednesday to 8,561, symptoms for reinfected patients and those
infected after vaccination appear to be mild.
"Some evidence from South Africa suggests that it may
actually cause more mild illness but … I caution you that a lot of the patients
South Africa initially were among young university students," Dr. Carlos
Del Rio, an infectious diseases expert at Emory University in Atlanta, said on
Thursday during an online briefing from the Infectious Diseases Society of
America.
Is Omicron a 'less fit' version of coronavirus?
While data on real world infections continues to emerge,
scientists are conducting laboratory studies to decipher Omicron. The variant
has about 50 mutations not seen in combination before, including more than 30
mutations on the spike protein the coronavirus uses to attach to human cells.
Vaccines in current use target that spike protein.
"Typically when viruses accumulate a lot of mutations they
lose some fitness," said Dr. John Wherry, director of the Penn Institute
for Immunology in Philadelphia. Certain Omicron mutations may impair the
ability of the virus to cleave, changing the behavior of the spike protein, he
said.
Can Omicron overcome immunity from vaccines or infection?
The fast rise of Omicron cases in South Africa could be due to
its capability to infect people who have been vaccinated or recovered from
COVID-19 caused by other variants, according to the scientific journal Nature.
Researchers around the world are still working on measuring how
much the Omicron variant can evade immune response.
Previous studies showed Omicron's spike mutations suggested that
the variant will blunt the potency of neutralizing antibodies, which means the
variant can be resistant to the immunity triggered by the vaccines or the
previous infection.
However, it doesn't mean the immune responses will serve no
protection against the variant. According to Nature, the modest levels of
neutralizing antibodies may protect people from severe illness caused by
COVID-19.
Will Omicron become the dominant variant?
If Omicron does become dominant, but causes milder illness, it
could mark a turning point toward the virus eventually becoming a seasonal
threat, like influenza, said Sumit Chanda, an infectious disease researcher at
the Scripps Research Department of Immunology and Microbiology in San Diego.
The European Union's public health agency said on Thursday the
Omicron variant could be responsible for more than half of all COVID-19
infections in Europe within a few months.
Although it's still unclear how effective the vaccines and the
booster shots will be against the variant, Paul Bieniasz, a virologist at
Rockefeller University in New York City, and his team have already found some
evidence showing people who are repeatedly exposed to the COVID-19 spike
protein, whether through infection or a booster shot, are "quite likely to
have neutralizing activity against Omicron," Bieniasz said in a September
2021 Nature paper.
While the research into Omicron is underway, disease experts say
people must remain vigilant against the coronavirus by getting either initial
vaccinations or booster shots, as well as wearing masks in indoor or crowded
settings, ventilating rooms and washing hands.